abstract：:Research participants require ongoing protection of the kind already established in law and regulation. However, "special scrutiny" for certain types of research is also needed. Three criteria for special scrutiny are 1) research that involves initial experiences of translating new scientific advances into humans, esp...

journal_title：Annals of internal medicine

authors： Levine C,Faden R,Grady C,Hammerschmidt D,Eckenwiler L,Sugarman J,Consortium to Examine Clinical Research Ethics.

更新日期：2004-02-03 00:00:00

abstract：BACKGROUND:AL amyloidosis is a fatal disease resulting from tissue deposition of amyloid fibrils derived from monoclonal immunoglobulin light chains. Treatment with oral chemotherapy is minimally effective. OBJECTIVE:To test survival and organ response in a large sample of patients treated with high-dose intravenous m...

journal_title：Annals of internal medicine

authors： Skinner M,Sanchorawala V,Seldin DC,Dember LM,Falk RH,Berk JL,Anderson JJ,O'Hara C,Finn KT,Libbey CA,Wiesman J,Quillen K,Swan N,Wright DG

更新日期：2004-01-20 00:00:00

abstract：:Ensuring patient safety is essential for better health care, but preoccupation with niches of medicine, such as patient safety, can inadvertently compromise outcomes if it distracts from other problems that pose a greater threat to health. The greatest benefit for the population comes from a comprehensive view of popu...

journal_title：Annals of internal medicine

authors： Woolf SH

更新日期：2004-01-06 00:00:00

abstract：PURPOSE:To compare the diagnostic accuracy of computed tomography (CT) and positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) for mediastinal staging in patients with non-small-cell lung cancer and to determine whether test results are conditionally dependent (the sensitivity and specificity of FDG-PET...

journal_title：Annals of internal medicine

authors： Gould MK,Kuschner WG,Rydzak CE,Maclean CC,Demas AN,Shigemitsu H,Chan JK,Owens DK

更新日期：2003-12-02 00:00:00

abstract：:Type 2 diabetes mellitus is a metabolic disease of carbohydrate metabolism. However, it should also be considered a vascular disease because diabetic patients have a strong predilection for atherosclerosis. With the increasing prevalence and earlier age at onset of diabetes, the projected effect of diabetes on cardiov...

journal_title：Annals of internal medicine

authors： Hurst RT,Lee RW

更新日期：2003-11-18 00:00:00

abstract：BACKGROUND:The optimal strategy to prevent recurrent presumed paradoxical emboli in patients with patent foramen ovale is unknown. PURPOSE:To synthesize the current knowledge about and qualitatively assess the relative benefits of transcatheter closure versus medical therapy for patent foramen ovale. DATA SOURCES:Eng...

journal_title：Annals of internal medicine

authors： Khairy P,O'Donnell CP,Landzberg MJ

更新日期：2003-11-04 00:00:00

abstract：:Given the low mortality and morbidity of the severe acute respiratory syndrome (SARS) compared with other public health scourges, is the attention devoted to it misdirected? The SARS experience has provided at least 4 enduring lessons. First, by providing a test of the capacity of each part of the public health system...

journal_title：Annals of internal medicine

authors： Emanuel EJ

更新日期：2003-10-07 00:00:00

abstract：:Abdominal aortic aneurysms (AAAs) occur in 1 of 20 older men, remain asymptomatic for many years, and, if left untreated, cause death from rupture in about one third of patients. Ultrasonography is a suitable screening test for AAA, and elective repair can prevent rupture. Although these features suggest a promising t...

journal_title：Annals of internal medicine

authors： Lederle FA

更新日期：2003-09-16 00:00:00

abstract：BACKGROUND:Although antiviral therapy is cost-effective in adults, its cost-effectiveness in older adults has not been studied. OBJECTIVE:To determine the cost-effectiveness of influenza testing and treatment strategies for older adults. DESIGN:Cost-utility decision model. DATA SOURCES:Clinical trials of antiviral d...

journal_title：Annals of internal medicine

authors： Rothberg MB,Bellantonio S,Rose DN

更新日期：2003-09-02 00:00:00

abstract：:Effective health care is a core determinant of successful aging, and medications are one of the most important therapeutic tools of health care providers. Most older adults use at least one prescription drug. Costs for these drugs are a substantial out-of-pocket expense for Medicare beneficiaries, and low-income older...

journal_title：Annals of internal medicine

authors： Murray MD,Callahan CM

更新日期：2003-09-02 00:00:00

abstract：BACKGROUND:Although few retrospective studies of high altitude have reported that obesity might be associated with the development of acute mountain sickness (AMS), this association has not been studied prospectively. OBJECTIVE:To determine whether obesity is associated with the development of AMS. DESIGN:Obese and n...

journal_title：Annals of internal medicine

authors： Ri-Li G,Chase PJ,Witkowski S,Wyrick BL,Stone JA,Levine BD,Babb TG

更新日期：2003-08-19 00:00:00

abstract：BACKGROUND:Residual renal function is an important determinant of mortality and morbidity in patients receiving peritoneal dialysis. However, few studies have evaluated therapeutic approaches for preserving residual renal function after the initiation of dialysis. OBJECTIVE:To test the hypothesis that the angiotensin-...

journal_title：Annals of internal medicine

authors： Li PK,Chow KM,Wong TY,Leung CB,Szeto CC

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Antioxidant vitamins are thought to play a role in atherosclerosis. Supplementation of these nutrients has been explored as a means of reducing cardiovascular morbidity and mortality. PURPOSE:To assess the evidence of the effectiveness of vitamin supplementation, specifically vitamins A, C, and E; beta-caro...

journal_title：Annals of internal medicine

authors： Morris CD,Carson S

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Pulmonary embolism is a common clinical disorder that is associated with high morbidity and mortality if untreated. It is important to confirm or rule out the diagnosis in patients with clinical suspicion of the disease. PURPOSE:To evaluate various diagnostic strategies for excluding pulmonary embolism. DA...

journal_title：Annals of internal medicine

authors： Kruip MJ,Leclercq MG,van der Heul C,Prins MH,Büller HR

更新日期：2003-06-17 00:00:00

abstract：BACKGROUND:Few treatments for back pain are supported by strong scientific evidence. Conventional treatments, although widely used, have had limited success. Dissatisfied patients have, therefore, turned to complementary and alternative medical therapies and providers for care for back pain. PURPOSE:To provide a rigor...

journal_title：Annals of internal medicine

authors： Cherkin DC,Sherman KJ,Deyo RA,Shekelle PG

更新日期：2003-06-03 00:00:00

abstract：BACKGROUND:Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT). OBJECTIVE:To determine whether a negative result on a quantitative latex D dimer assay eliminates the need for further investigation in patients with...

journal_title：Annals of internal medicine

authors： Bates SM,Kearon C,Crowther M,Linkins L,O'Donnell M,Douketis J,Lee AY,Weitz JI,Johnston M,Ginsberg JS

更新日期：2003-05-20 00:00:00

abstract：:This paper is part 1 of a 2-part series on interpretation of 12-lead resting electrocardiograms (ECGs). Part 1 is a position paper that presents recommendations for initial competency, competency assessment, and maintenance of competency on ECG interpretation, as well as recommendations for the role of computer-assist...

journal_title：Annals of internal medicine

authors： Salerno SM,Alguire PC,Waxman HS,American College of Physicians.

更新日期：2003-05-06 00:00:00

abstract：:All practicing physicians should be prepared to respond to requests from patients for advice about participating in clinical trials research. Even physicians who choose not to conduct clinical trials but rather devote their practice to clinical care may have patients who consider volunteering for research. In advising...

journal_title：Annals of internal medicine

authors： Chen DT,Miller FG,Rosenstein DL

更新日期：2003-04-15 00:00:00

abstract：:The 1950s witnessed prodigious growth in our knowledge of the chemical nature of the gene, the mechanisms by which the information inherent in its sequence of nucleotide units was conveyed to the cell's machinery for synthesizing proteins, and the mode of operation of that machinery. Watson and Crick raised the curtai...

journal_title：Annals of internal medicine

authors： Hoagland MB

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Some physicians seem to be willing to sanction deception of insurance companies. Little is known about public attitudes regarding this practice. OBJECTIVE:To assess public attitudes regarding physician deception of insurance companies. DESIGN:Cross-sectional survey using clinical vignettes. SETTING:Philad...

journal_title：Annals of internal medicine

authors： Alexander GC,Werner RM,Fagerlin A,Ubel PA

更新日期：2003-03-18 00:00:00

abstract：BACKGROUND:Although weight loss improves risk factors for cardiovascular and metabolic disease, it is unclear whether intentional weight loss reduces mortality rates. OBJECTIVE:To examine the relationships among intention to lose weight, weight loss, and all-cause mortality. DESIGN:Prospective cohort study using a pr...

journal_title：Annals of internal medicine

authors： Gregg EW,Gerzoff RB,Thompson TJ,Williamson DF

更新日期：2003-03-04 00:00:00

abstract：:Position statements opposing legalization of physician-assisted suicide by organizations such as the American College of Physicians-American Society of Internal Medicine rightly emphasize that palliative care should be the standard of care for the dying, and that the inadequacies that exist in its delivery should be r...

journal_title：Annals of internal medicine

authors： Quill TE,Cassel CK

更新日期：2003-02-04 00:00:00

abstract：BACKGROUND:Although the efficacy of adjuvant chemotherapy in prolonging survival for women with breast cancer has been well documented, limited population-based information is available on the actual use of chemotherapy. OBJECTIVE:To examine the relationship between age and chemotherapy use. DESIGN:Cohort study. SET...

journal_title：Annals of internal medicine

authors： Du XL,Key CR,Osborne C,Mahnken JD,Goodwin JS

更新日期：2003-01-21 00:00:00

abstract：BACKGROUND:The renin-angiotensin system is involved in adipocyte growth and differentiation and possibly in adipose tissue metabolism. OBJECTIVE:To investigate the association of polymorphism in the angiotensin-converting enzyme (ACE) I/D gene, angiotensinogen M235T gene, and angiotensin II type 1 receptor A1166C gene...

journal_title：Annals of internal medicine

authors： Strazzullo P,Iacone R,Iacoviello L,Russo O,Barba G,Russo P,D'Orazio A,Barbato A,Cappuccio FP,Farinaro E,Siani A,Olivetti Prospective Heart Study.

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:The optimum duration of anticoagulant therapy after an episode of deep venous thrombosis (DVT) is controversial. Contributing to the controversy is uncertainty about whether residual venous thrombosis, as assessed by repeated ultrasonography over time, increases the risk for recurrent thromboembolism. OBJEC...

journal_title：Annals of internal medicine

authors： Prandoni P,Lensing AW,Prins MH,Bernardi E,Marchiori A,Bagatella P,Frulla M,Mosena L,Tormene D,Piccioli A,Simioni P,Girolami A

更新日期：2002-12-17 00:00:00

abstract：BACKGROUND:Mounting evidence indicates that subclinical thyroid dysfunction has important clinical effects and prognostic implications, supporting the view that it is not a compensated biochemical change sensu strictu. PURPOSE:To review clinical information on the effects of subclinical thyroid dysfunction on the hear...

journal_title：Annals of internal medicine

authors： Biondi B,Palmieri EA,Lombardi G,Fazio S

更新日期：2002-12-03 00:00:00

abstract：:Acute coronary syndromes--unstable angina, myocardial infarction, and sudden cardiac death--are caused by acute disruption of an unstable coronary atheroma. Unstable plaques have three histologic characteristics: a large lipid core, many inflammatory cells, and a thin fibrous cap. Because the unstable plaque is not ne...

journal_title：Annals of internal medicine

authors： Forrester JS

更新日期：2002-11-19 00:00:00

abstract：:Opioid dependence is a chronic relapsing medical condition with substantial health and societal complications. Recent federal initiatives are designed to enhance the medical treatment of patients with opioid dependence and will expand the role of internists in the care of these patients. These initiatives include a pr...

journal_title：Annals of internal medicine

authors： Fiellin DA,O'Connor PG

更新日期：2002-10-15 00:00:00

abstract：BACKGROUND:Questions remain about the importance of smoking and smoking cessation after incident myocardial infarction. OBJECTIVE:To assess the association between smoking status and risk for recurrent coronary events. DESIGN:Retrospective, population-based, inception cohort study. SETTING:Health maintenance organiz...

journal_title：Annals of internal medicine

authors： Rea TD,Heckbert SR,Kaplan RC,Smith NL,Lemaitre RN,Psaty BM

更新日期：2002-09-17 00:00:00

abstract：PURPOSE:To synthesize new data on breast cancer screening for the U.S. Preventive Services Task Force. DATA SOURCES:MEDLINE; the Cochrane Controlled Trials Registry; and reference lists of reviews, editorials, and original studies. STUDY SELECTION:Eight randomized, controlled trials of mammography and 2 trials evalua...

journal_title：Annals of internal medicine

authors： Humphrey LL,Helfand M,Chan BK,Woolf SH

更新日期：2002-09-03 00:00:00

abstract：BACKGROUND:A common criticism of randomized, controlled trials (RCTs) is that the enrollment process may be highly selective and those who enroll may not represent persons in the general population. The recruitment process reported in published RCTs has not been systematically evaluated. OBJECTIVE:To determine whether...

journal_title：Annals of internal medicine

authors： Gross CP,Mallory R,Heiat A,Krumholz HM

更新日期：2002-07-02 00:00:00

abstract：PURPOSE:Chemoprevention offers promise as a strategy for reducing morbidity and mortality from breast cancer in women. This review examined the evidence for the effectiveness of chemoprevention in women without a history of breast cancer. DATA SOURCES:MEDLINE (1966 to December 2001). STUDY SELECTION:English-language,...

journal_title：Annals of internal medicine

authors： Kinsinger LS,Harris R,Woolf SH,Sox HC,Lohr KN

更新日期：2002-07-02 00:00:00

abstract：BACKGROUND:The optimal strategy for diagnosis of deep venous thrombosis (DVT) is less well established for the upper extremities than for the lower extremities. Duplex color ultrasonography can be difficult to perform in the upper extremities because of their anatomy, and contrast venography is often indicated. Moreove...

journal_title：Annals of internal medicine

authors： Baarslag HJ,van Beek EJ,Koopman MM,Reekers JA

更新日期：2002-06-18 00:00:00

abstract：:In alternative medicine, the main question regarding placebo has been whether a given therapy has more than a placebo effect. Just as mainstream medicine ignores the clinical significance of its own placebo effect, the placebo effect of unconventional medicine is disregarded except for polemics. This essay looks at th...

journal_title：Annals of internal medicine

authors： Kaptchuk TJ

更新日期：2002-06-04 00:00:00

abstract：BACKGROUND:Although some studies suggest that access to cardiac procedures may differ by sex, others have found no evidence of gender bias in cardiac care. OBJECTIVE:To study rates of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery in men and women after cardiac catheterization....

journal_title：Annals of internal medicine

authors： Ghali WA,Faris PD,Galbraith PD,Norris CM,Curtis MJ,Saunders LD,Dzavik V,Mitchell LB,Knudtson ML,Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators.

更新日期：2002-05-21 00:00:00

abstract：BACKGROUND:Recent guidelines for adult prevention do not recommend a comprehensive annual physical examination, but current public expectations in light of this change are unknown. OBJECTIVE:To determine public belief in the need for and content of an annual physical examination and to examine the effect of financial ...

journal_title：Annals of internal medicine

authors： Oboler SK,Prochazka AV,Gonzales R,Xu S,Anderson RJ

更新日期：2002-05-07 00:00:00

abstract：:We provide a new perspective with which to understand what for a half century has been known as the "placebo effect." We argue that, as currently used, the concept includes much that has nothing to do with placebos, confusing the most interesting and important aspects of the phenomenon. We propose a new way to underst...

journal_title：Annals of internal medicine

authors： Moerman DE,Jonas WB

更新日期：2002-03-19 00:00:00

abstract：:Traditionally, acupuncture is embedded in naturalistic theories that are compatible with Confucianism and Taoism. Such ideas as yin-yang, qi, dampness, and wind represent East Asian conceptual frameworks that emphasize the reliability of ordinary, human sensory awareness. Many physicians who practice acupuncture rejec...

journal_title：Annals of internal medicine

authors： Kaptchuk TJ

更新日期：2002-03-05 00:00:00

abstract：:Congenital adrenal hyperplasia describes a group of inherited autosomal recessive disorders characterized by an enzymatic defect in cortisol biosynthesis, compensatory increases in corticotropin secretion, and adrenocortical hyperplasia. 21-Hydroxylase deficiency is responsible for more than 95% of cases and is one of...

journal_title：Annals of internal medicine

authors： Merke DP,Bornstein SR,Avila NA,Chrousos GP

更新日期：2002-02-19 00:00:00

abstract：BACKGROUND:Current magnetic resonance techniques generate high signal from venous blood and show thrombi as filling defects. Magnetic resonance direct thrombus imaging (MRDTI) directly visualizes acute thrombus. OBJECTIVE:To determine the accuracy of MRDTI for diagnosis of acute symptomatic deep venous thrombosis (DVT...

journal_title：Annals of internal medicine

authors： Fraser DG,Moody AR,Morgan PS,Martel AL,Davidson I

更新日期：2002-01-15 00:00:00